abstract：:Topoisomerase IIalpha (topoIIalpha) is an enzyme required for DNA replication and a molecular target for drugs called anthracyclines. The topoIIalpha gene (TOP2A) is located close to the HER-2/neu oncogene (HER2). We assessed gastric cancers to (1) clarify the relationship between gene amplification and protein overex...

journal_title：Human pathology

authors： Kanta SY,Yamane T,Dobashi Y,Mitsui F,Kono K,Ooi A

更新日期：2006-10-01 00:00:00

abstract：:Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma...

journal_title：Human pathology

authors： Tavora F,Gonzalez-Cuyar LF,Sun CC,Burke A,Zhao XF

更新日期：2006-09-01 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 subtypes with either somatically mutated or unmutated immunoglobulin heavy-chain variable region (IgVH) genes. A prognostic significance of the infiltration pattern in bone marrow trephine biopsy has been described before. The combined pattern analysis...

journal_title：Human pathology

authors： Schade U,Bock O,Vornhusen S,Jäger A,Büsche G,Lehmann U,Kreipe H

更新日期：2006-09-01 00:00:00

abstract：:Hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) protein, a member of the reg family, is constitutively expressed by some specialized epithelial cell subsets in the digestive tract and the pancreas. We performed a detailed analysis of the expression of HIP/PAP protein in normal digestive en...

journal_title：Human pathology

authors： Hervieu V,Christa L,Gouysse G,Bouvier R,Chayvialle JA,Bréchot C,Scoazec JY

更新日期：2006-08-01 00:00:00

abstract：:Current regulations require that departments of pathology have a structured and active program of quality assurance (QA) and quality improvement (QI), with the goals of enhancing patient safety, minimizing error, ensuring timely delivery of reports, and monitoring physician competence. Types of potential error may evo...

journal_title：Human pathology

authors： Association Of Directors Of Anatomic And Surgical Pathology.,Nakhleh R,Coffin C,Cooper K

更新日期：2006-08-01 00:00:00

abstract：:Chondroblastoma (CBL) is a benign neoplasm of bone for which the genomic characteristics remain unclear. We compared the status of allelic losses of CBL with that seen in a set of chondrosarcomas (CS) to determine whether differences in their natural history and behavior are also reflected genetically. Eleven cases of...

journal_title：Human pathology

authors： Papachristou DJ,Goodman MA,Cieply K,Hunt JL,Rao UN

更新日期：2006-07-01 00:00:00

abstract：:The distinction between Spitz nevus and melanoma is currently possible, applying a set of definite histological criteria. However, in certain lesions deviating from the stereotypical morphology of classic Spitz nevi ("atypical Spitz tumors"), the differentiation between benign and malignant cases appears problematic b...

journal_title：Human pathology

authors： Urso C,Borgognoni L,Saieva C,Ferrara G,Tinacci G,Begliomini B,Reali UM

更新日期：2006-07-01 00:00:00

abstract：:Natural killer (NK)/T-cell lymphomas represent a rare type of lymphoma derived from either activated NK cells or, rarely, cytotoxic T cells. These lesions are most commonly extranodal and tend to present as destructive lesions within the midline facial structures. Other than the nasal cavity and paranasal sinuses, sev...

journal_title：Human pathology

authors： Kaluza V,Rao DS,Said JW,de Vos S

更新日期：2006-06-01 00:00:00

abstract：:Alpha-methyl CoA racemase (AMACR), a new molecular marker for prostate cancer, has been recently reported to be one of the most highly expressed genes in papillary renal cell carcinomas (RCCs). We tested the diagnostic usefulness of AMACR antibody in a series of 110 renal tumors: 53 papillary RCCs (33 type 1, 20 type ...

journal_title：Human pathology

authors： Molinié V,Balaton A,Rotman S,Mansouri D,De Pinieux I,Homsi T,Guillou L

更新日期：2006-06-01 00:00:00

abstract：:Plakophilins (PKPs) are a set of 3 constitutive armadillo repeat proteins of the desmosomal plaque, termed PKP 1, PKP 2, and PKP 3, which have been shown to be functionally relevant for desmosomal adhesion. We have performed a systematic immunohistochemical study of the 3 PKPs in oral and pharyngeal squamous cell carc...

journal_title：Human pathology

authors： Schwarz J,Ayim A,Schmidt A,Jäger S,Koch S,Baumann R,Dünne AA,Moll R

更新日期：2006-05-01 00:00:00

abstract：:In a recent evaluation by comparative genomic hybridization, we demonstrated chromosome 14q31-32.1 to be frequently deleted in adenocarcinomas of the gastroesophageal junction. This suggests the presence of a tumor suppressor gene in the deleted region. In the present study, we have performed a detailed loss of hetero...

journal_title：Human pathology

authors： Dinjens WN,Koppert LB,Dezentjé DA,Abbou M,van Ballegooijen ES,Sleddens HF,van Dekken H,Tilanus HW,Wijnhoven BP

更新日期：2006-05-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) exon 18-21 mutations were shown to be highly predictive of response to gefitinib (Iressa) therapy in lung cancer. Studies on Western and Japanese lung cancers have indicated substantial differences in the EGFR mutation frequency between these populations. To investigate the prev...

journal_title：Human pathology

authors： Al-Kuraya K,Siraj AK,Bavi P,Al-Jommah N,Ezzat A,Sheikh S,Amr S,Al-Dayel F,Simon R,Guido S

更新日期：2006-04-01 00:00:00

abstract：:Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic ca...

journal_title：Human pathology

authors： Chen X,Zhao J,Salim S,Garcia FU

更新日期：2006-03-01 00:00:00

abstract：:In a large-scale analysis of gene expression in pancreatic cancer, we isolated the homologue of the mouse Rab20. The mouse protein was previously identified during a search for novel Rab proteins, a family of small GTP-binding proteins involved in the regulation of intracellular vesicular transport. The Rab20 protein ...

journal_title：Human pathology

authors： Amillet JM,Ferbus D,Real FX,Antony C,Muleris M,Gress TM,Goubin G

更新日期：2006-03-01 00:00:00

abstract：:To examine the importance of prohibitin 1 and c-Met/hepatocyte growth factor receptor (HGFR) expression in human cervical adenocarcinomas, 85 patients (69 with invasive adenocarcinoma [ACA] and 16 with adenocarcinoma in situ [AIS]) were studied using immunohistochemistry. High prohibitin 1 expression was found in 51 (...

journal_title：Human pathology

authors： Tsai HW,Chow NH,Lin CP,Chan SH,Chou CY,Ho CL

更新日期：2006-02-01 00:00:00

abstract：:We investigated whether histological chorioamnionitis (HCA) is a risk factor predisposing to leukemoid reaction (LR) and whether LR is associated with the preterm parturition syndrome and the systemic fetal inflammation response syndrome. A prospective histological study on placentas was performed in preterm infants (...

journal_title：Human pathology

authors： Zanardo V,Vedovato S,Trevisanuto DD,Suppiej A,Cosmi E,Fais GF,Chiarelli S

更新日期：2006-01-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is one of the central signaling molecules found at focal adhesion sites, which are specific areas on the cell membrane where cells attach to extracellular matrix proteins. Focal adhesion kinase interacts with multiple signaling and adaptor molecules and effects several signaling pathways. O...

journal_title：Human pathology

authors： Madan R,Smolkin MB,Cocker R,Fayyad R,Oktay MH

更新日期：2006-01-01 00:00:00

abstract：:Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...

journal_title：Human pathology

authors： Ogawa T,Nagashima Y,Wada H,Akimoto K,Chiba Y,Nagatani T,Inayama Y,Yao M,Aoki I,Ikezawa Z

更新日期：2005-12-01 00:00:00

abstract：:There is limited published data regarding the significance of the number or position of nucleoli and the presence of apoptotic bodies in diagnostically challenging cases of adenocarcinoma of the prostate on needle biopsy material. One hundred consecutive prostate cancers on needle biopsy were sent because of diagnosti...

journal_title：Human pathology

authors： Aydin H,Zhou M,Herawi M,Epstein JI

更新日期：2005-11-01 00:00:00

abstract：:The aim of this study on a series of biopsies diagnosed as normal, metaplastic, low-grade squamous intraepithelial lesions (LSILs), and high-grade squamous intraepithelial lesions (HSILs) was dual: to determine the chronology of cell cycle and proliferation abnormalities after human papillomavirus infection during the...

journal_title：Human pathology

authors： Lorenzato M,Caudroy S,Bronner C,Evrard G,Simon M,Durlach A,Birembaut P,Clavel C

更新日期：2005-10-01 00:00:00

abstract：:Preserving small pieces of frozen tissue for possible future ancillary studies ("tumor banking") usually involves either placing a small piece of tissue in a cryovial and snap freezing it in liquid nitrogen or embedding and freezing the tissue in a block of cryopreservation medium, such as optimal cutting temperature ...

journal_title：Human pathology

authors： Loken SD,Demetrick DJ

更新日期：2005-09-01 00:00:00

abstract：:Cardiac troponin T (cTnT) is considered as a specific marker for acute myocardial infarction. Here, we present a case with elevated cTnT, determined by a third-generation assay, without signs of a myocardial lesion. Routine investigation of a 66-year-old female patient with indolent B-cell lymphoma revealed increased ...

journal_title：Human pathology

authors： Schwarzmeier JD,Hamwi A,Preisel M,Resl C,Preusser M,Sluga E,Horcher E,Shehata MM

更新日期：2005-08-01 00:00:00

abstract：:We aimed to study the expression of phosphorylated vascular endothelial growth factor receptor 2 (pVEGFR-2), a membrane-bound tyrosine kinase receptor to vascular endothelial growth factor, in 76 cases of leukemia and nonneoplastic myeloproliferative disease and in 8 reactive bone marrows. The microvessel density (MVD...

journal_title：Human pathology

authors： Zhang Y,Pillai G,Gatter K,Blázquez C,Turley H,Pezzella F,Watt SM

更新日期：2005-07-01 00:00:00

abstract：:The family of the poly(adenosine diphosphate-ribose) polymerase (PARP) proteins is directly involved in genomic stability, DNA repair, and apoptosis by DNA damage. In this study, we evaluated the role of PARP-1 in melanoma and its prognostic importance. We studied by immunohistochemistry and Western blot analysis PARP...

journal_title：Human pathology

authors： Staibano S,Pepe S,Lo Muzio L,Somma P,Mascolo M,Argenziano G,Scalvenzi M,Salvatore G,Fabbrocini G,Molea G,Bianco AR,Carlomagno C,De Rosa G

更新日期：2005-07-01 00:00:00

abstract：:Clinical stage I seminomas are effectively treated with surgery raising concerns as to when to give adjuvant radiation therapy given the risk of secondary malignancies. A recent randomized trial found tumor size and rete testis invasion to be the strongest predictors of relapse in clinical stage I seminomas. These 2 p...

journal_title：Human pathology

authors： Browne TJ,Richie JP,Gilligan TD,Rubin MA

更新日期：2005-06-01 00:00:00

abstract：:Cribriform and/or papillary prostatic lesions observed on limited tissue, such as needle biopsy, can pose diagnostic dilemmas. One such area of difficulty is the distinction between papillary and/or cribriform prostatic high-grade prostatic intraepithelial neoplasia (HG-PIN) and ductal adenocarcinoma. Over 48 months, ...

journal_title：Human pathology

authors： Rioux-Leclercq N,Leray E,Patard JJ,Lobel B,Guillé F,Jouan F,Bellaud P,Epstein JI

更新日期：2005-05-01 00:00:00

abstract：:Acute rejection is an extremely common complication of lung transplantation. (1) To appreciate the interobserver variation in the interpretation of histologic findings and (2) to assess the efficacy of transbronchial biopsy (TBB) for acute rejection diagnosis and associated diseases, particularly infection, we perform...

journal_title：Human pathology

authors： Colombat M,Groussard O,Lautrette A,Thabut G,Marrash-Chahla R,Brugière O,Mal H,Lesèche G,Fournier M,Degott C

更新日期：2005-04-01 00:00:00

abstract：:In 1821 Napoleon died in exile on the Island of St. Helena. Although the autopsy had suggested stomach cancer as the cause of death, in 1961 an elevated arsenic concentration was found in Napoleon's hair. This finding elicited numerous theories of conspiracy, treachery, and poisoning. Most recent reports even suggeste...

journal_title：Human pathology

authors： Lugli A,Lugli AK,Horcic M

更新日期：2005-04-01 00:00:00

abstract：:C- kit encodes the membrane-bound tyrosine kinase KIT, whose expression has been identified in several types of human neoplasms. Recently, KIT has been reported to be a marker for chromophobe renal cell carcinoma (RCC) and renal angiomyolipoma. However, expression of this molecule has not been adequately studied in ot...

journal_title：Human pathology

authors： Huo L,Sugimura J,Tretiakova MS,Patton KT,Gupta R,Popov B,Laskin WB,Yeldandi A,Teh BT,Yang XJ

更新日期：2005-03-01 00:00:00

abstract：:This report describes a vasculitis and subsequently developing angiodestructive lymphoma in an 11-year-old Japanese-Filipino girl exhibiting mosquito allergy with the background of chronic active Epstein-Barr virus (EBV) infection. She developed necrotic skin ulcer at the site of mosquito bite, and histopathological e...

journal_title：Human pathology

authors： Kanno H,Onodera H,Endo M,Maeda F,Chida S,Akasaka T,Sawai T

更新日期：2005-02-01 00:00:00

abstract：:It is impossible to overstate the importance of XML (eXtensible Markup Language) as a data organization tool. With XML, pathologists can annotate all of their data (clinical and anatomic) in a format that can transform every pathology report into a database, without compromising narrative structure. The purpose of thi...

journal_title：Human pathology

authors： Berman JJ

更新日期：2005-02-01 00:00:00

abstract：:Botryomycosis is a rare bacterial infection of the skin and, rarely, viscera that is characterized by the formation of characteristic hyaline grains. We encountered a patient with Erysipelothrix rhusiopathiae endocarditis who developed visceral botryomycosis. He was a 54-year-old black man who presented in sepsis with...

journal_title：Human pathology

authors： Carson HJ,Perkins JT

更新日期：2005-01-01 00:00:00

abstract：:Supratentorial primitive neuroectodermal tumors (SPNETs) and medulloblastomas (MBs) are histologically similar intracranial tumors found in different anatomic locations of the brain. Our group has previously demonstrated that loss of chromosome 8p is a frequent event in MBs. The aim of this study was to evaluate wheth...

journal_title：Human pathology

authors： Pang JC,Chang Q,Chung YF,Teo JG,Poon WS,Zhou LF,Kong X,Ng HK

更新日期：2005-01-01 00:00:00

abstract：:Intraductal papillary neoplasm of the liver (IPNL) is a precursor lesion of intrahepatic cholangiocarcinoma (ICC) arising in hepatolithiasis. In this study, 98 foci of IPNL identified in 39 surgically resected hepatolithiatic livers were investigated for expression of p16INK4a, cyclin D1, p21WAF1/CIP1, p53, mouse doub...

journal_title：Human pathology

authors： Ishikawa A,Sasaki M,Sato Y,Ohira S,Chen MF,Huang SF,Oda K,Nimura Y,Nakanuma Y

更新日期：2004-12-01 00:00:00

abstract：:Anaplastic meningiomas (MIIIs) and meningeal hemangiopericytomas (HPCs) display significant morphologic and immunohistochemical overlap, including occasional cases of otherwise classic HPC with focal epithelial membrane antigen (EMA) positivity. The availability of several new biomarkers prompted us to examine the pot...

journal_title：Human pathology

authors： Rajaram V,Brat DJ,Perry A

更新日期：2004-11-01 00:00:00

abstract：:Clusterin has been reported to play a significant role in tumorigenesis, and its overexpression occurs in various human malignancies. We examine the clusterin overexpression in human hepatocellular carcinoma (HCC) and verify its clinical usefulness as a candidate biomarker by clinicopathologic and survival analysis. W...

journal_title：Human pathology

authors： Kang YK,Hong SW,Lee H,Kim WH

更新日期：2004-11-01 00:00:00

abstract：:Blue nevus is an uncommon pigmented tumor of dermal melanocytes that has traditionally been classified into common and cellular variant. It is usually a skin tumor in adults but can become apparent in early childhood or even be present at birth. Malignant blue nevus is a rare melanocytic tumor of the skin arising from...

journal_title：Human pathology

authors： Popović M,Dolenc-Strazar Z,Anzic J,Luzar B

更新日期：2004-10-01 00:00:00

abstract：:Telomerase is expressed in many human cancers and cell lines and is thought to contribute to their immortality. To date, little is known about the expression of telomerase in nonepithelial tumors. The objective of this study was to evaluate the expression of human telomerase reverse transcriptase (hTERT) in gastrointe...

journal_title：Human pathology

authors： Sabah M,Cummins R,Leader M,Kay E

更新日期：2004-10-01 00:00:00

abstract：:Idiopathic hypereosinophilic syndrome (HES) consists of a prolonged state of eosinophilia of unknown origin with organ involvement. We describe the case of a patient who developed fatal eosinophilic myocarditis. A 23-year-old woman with an 8-month history of eosinophilia presented with symptoms of myocarditis. Histolo...

journal_title：Human pathology

authors： Corradi D,Vaglio A,Maestri R,Legname V,Leonardi G,Bartoloni G,Buzio C

更新日期：2004-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is frequent in human immunodeficiency virus (HIV)-infected patients. It is known to have an aggressive course in significantly immunosuppressed patients, and cirrhosis C has become one of the main causes of mortality in HIV-HCV coinfected patients since the improvement of antiretrovir...

journal_title：Human pathology

authors： Rullier A,Trimoulet P,Neau D,Bernard PH,Foucher J,Lacoste D,Winnock M,Urbaniak R,Ballardini G,Balabaud C,Bioulac-Sage P,Le Bail B

更新日期：2004-09-01 00:00:00